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Mutational Heterogeneity In Human Cancers Origin And Consequences Pdf

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Despite numerous advances in cell biology, genetics, and developmental biology, cancer origin has been attributed to genetic mechanisms primarily involving mutations. Embryologists have expressed timidly cancer embryological origin with little success in leveraging the discussion that cancer could involve a set of conventional cellular processes used to build the embryo during morphogenesis. The concept of environment is often used with a broad scope and includes all nongenetic factors such as diet, lifestyle, and infectious agents. At the current juncture of the XXI century, cancer disease should not be dissociated from the environment and external stimuli, which are considered as the causes of most human cancers [ 1 , 2 ].

Epigenetic heterogeneity in cancer

Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. The risk of developing certain cancers can be reduced by not smoking, maintaining a healthy weight, limiting alcohol intake, eating plenty of vegetables , fruits , and whole grains , vaccination against certain infectious diseases, limiting consumption of processed meat and red meat , and limiting exposure to direct sunlight. In , about Greek physicians Hippocrates and Galen, among others, noted similarity of crabs to some tumors with swollen veins. The word was introduced in English in the modern medical sense around

The sheer size of the human genome makes it improbable that identical somatic mutations at the exact same position are observed in multiple tumours solely by chance. The scarcity of cancer driver mutations also precludes positive selection as the sole explanation. Therefore, recurrent mutations may be highly informative of characteristics of mutational processes. We describe each genome with 13 recurrence-based and 29 general mutational features. Using principal component analysis we reduce the dimensionality and create independent features.

Although not all somatic mutations are cancer drivers, their mutational signatures, i. However, the mechanisms underlying nearly one-third of all mutational signatures are not yet understood. The signatures with established etiology and those with hitherto unknown origin appear to have some differences in strand bias, GC content and nucleotide context diversity. While nucleotide contexts might be adequate to establish etiologies of some mutational signatures, in other cases additional features, such as broader epi genomic contexts, including chromatin, replication timing, processivity and local mutational patterns, may help fully understand the underlying DNA damage and repair processes. Nonetheless, remarkable progress in characterization of mutational signatures has provided fundamental insights into the biology of cancer, informed disease etiology and opened up new opportunities for cancer prevention, risk management, and therapeutic decision making. Genomic instability is a hallmark of all cancers. Cancer genomes typically harbor 10 3 —10 5 somatic point mutations, along with other classes of genomic alterations, including insertions and deletions InDels , copy number variations, rearrangements and ploidy changes 1 , 2.

Molecular heterogeneity in lung cancer: from mechanisms of origin to clinical implications

Metrics details. Phenotypic and functional heterogeneity is one of the hallmarks of human cancers. Tumor genotype variations among tumors within different patients are known as interpatient heterogeneity, and variability among multiple tumors of the same type arising in the same patient is referred to as intra-patient heterogeneity. Subpopulations of cancer cells with distinct phenotypic and molecular features within a tumor are called intratumor heterogeneity ITH. Since Nowell proposed the clonal evolution of tumor cell populations in , tumor heterogeneity, especially ITH, was actively studied. Research has focused on the genetic basis of cancer, particularly mutational activation of oncogenes or inactivation of tumor-suppressor genes TSGs.

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Somatic mutations in cancer genomes are caused by multiple mutational processes, each of which generates a characteristic mutational signature 1.


The impact of DNA sequencing on future cancer research and personalized therapy is likely to be profound and merits critical evaluation.


The repertoire of mutational signatures in human cancer

International Journal of Biological Sciences. Journal of Cancer. Journal of Genomics. Global reach, higher impact.

Clinical relevance of mutant-allele tumor heterogeneity and lung adenocarcinoma

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INTRODUCTION

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4 Comments

Ancelote P. 13.12.2020 at 21:02

The incidence and mortality of lung cancer have increased steadily worldwide in the past several decades 1.

Walkyria M. 15.12.2020 at 05:14

Mutational Heterogeneity in Human Cancers: Origin and Consequences The impact of DNA sequencing on future cancer research and.

Ninfa V. 15.12.2020 at 15:40

The sources of mutations in cancer are diverse, and the complexity of those found to Mutational Heterogeneity in Human Cancers: Origin and Consequences.

Erich F. 17.12.2020 at 18:17

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